Milk oral immunotherapy is effective in school-aged children.

Milk oral immunotherapy is effective in school-aged children.

Salmivesi S, et al.

Acta Paediatr. 2012 Aug 17.

Aims:  To study the efficacy of oral immunotherapy (OIT) in schoolchildren with cow`s milk (CM) allergy (CMA). Methods:  Twenty-eight children aged 6-14 years with CMA documented by oral challenge were enrolled into a randomized, double-blind, placebo-controlled OIT study. In the active treatment, CM protein amount was increased during 23 weeks from 0.06 mg to a maximum of 6400 mg (200 mL of milk). Results:  Twenty-four (86%) patients completed the protocol: 16/18 in active and 8/10 in placebo groups. All children in the active and 2/3 in the placebo group suffered from symptoms considered by the parents as induced by milk. The children were contacted by phone 12 months later, and 13(81%) used daily CM or milk products corresponding 6400 mg of CM protein. After double-blind OIT, all 10 children in the placebo group completed successfully an open-label OIT by an identical protocol, and all used daily CM or milk products 6 months later. Three to 3.5 years later, one child more had discontinued daily milk use. Thus, the long-term success rate was 22/28(79%). Conclusions:  This placebo-controlled, double-blind study confirmed that OIT was effective in desensitizing schoolchildren with CMA. With occasional exceptions, the reached desensitization sustained for more than three years.

Source: Pediatric Research Centre, Tampere University and Tampere University Hospital, Tampere, Finland Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland Allergy Centre, Tampere University Hospital, Tampere, Finland.


Tinggalkan Balasan

Isikan data di bawah atau klik salah satu ikon untuk log in:


You are commenting using your account. Logout / Ubah )

Gambar Twitter

You are commenting using your Twitter account. Logout / Ubah )

Foto Facebook

You are commenting using your Facebook account. Logout / Ubah )

Foto Google+

You are commenting using your Google+ account. Logout / Ubah )

Connecting to %s