Milk oral immunotherapy is effective in school-aged children.
Salmivesi S, et al.
Acta Paediatr. 2012 Aug 17.
Aims: To study the efficacy of oral immunotherapy (OIT) in schoolchildren with cow`s milk (CM) allergy (CMA). Methods: Twenty-eight children aged 6-14 years with CMA documented by oral challenge were enrolled into a randomized, double-blind, placebo-controlled OIT study. In the active treatment, CM protein amount was increased during 23 weeks from 0.06 mg to a maximum of 6400 mg (200 mL of milk). Results: Twenty-four (86%) patients completed the protocol: 16/18 in active and 8/10 in placebo groups. All children in the active and 2/3 in the placebo group suffered from symptoms considered by the parents as induced by milk. The children were contacted by phone 12 months later, and 13(81%) used daily CM or milk products corresponding 6400 mg of CM protein. After double-blind OIT, all 10 children in the placebo group completed successfully an open-label OIT by an identical protocol, and all used daily CM or milk products 6 months later. Three to 3.5 years later, one child more had discontinued daily milk use. Thus, the long-term success rate was 22/28(79%). Conclusions: This placebo-controlled, double-blind study confirmed that OIT was effective in desensitizing schoolchildren with CMA. With occasional exceptions, the reached desensitization sustained for more than three years.
Source: Pediatric Research Centre, Tampere University and Tampere University Hospital, Tampere, Finland Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland Allergy Centre, Tampere University Hospital, Tampere, Finland.